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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM7012-10mM | 胆酸(98%, HPLC) | 10mM×0.2ml | 76.00元 |
| SM7012-25mg | 胆酸(98%, HPLC) | 25mg | 96.00元 |
| SM7012-100mg | 胆酸(98%, HPLC) | 100mg | 326.00元 |
| 中文名 | 胆酸 |
| 英文名 | Cholic acid |
| 中文别名 | 胆汁酸；胆甾烷酸 |
| 英文别名 | - |
| 来源 | 牛黄Bos taurus domesticus Gmelin |
| 化合物类型 | 甾体类(Steroids)>胆汁酸 |
| 化学式 | C24H40O5 |
| 分子量 | 408.58 |
| CAS号 | 81-25-4 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
DMSO: ≥ 50 mg/ml (122.38 mM) Water: ＜0.1 mg/ml (insoluble) |
| 溶液配制 | 5mg加入1.22ml DMSO，或者每4.09mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. | ||||
| 信号通路 | Endogenous Metabolite | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Cholic acid competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway. | ||||
| 体内研究 | Cholic acid feeding leads to increased CYP2D6 expression in CYP2D6-humanized mice. As a cholestasis model, Tg-CYP2D6 mice are fed a Cholic acid (CA)-supplemented diet for over 1 week. The treatment is known to increase bile acid pool size by 2-fold and to replace ~90% of bile acids with CA, recapitulating the features of cholestatic conditions in humans. | ||||
| 临床实验 | NCT01115582: Inborn Errors of Bile Acid Synthesis, Phase 3; NCT01438411: Bile Acid Synthesis Defect, Phase 3. | ||||
1.Li Y, et al. Int J Nanomedicine. 2017,12:1673-1684.
2.Pan X, et al. Drug Metab Dispos. 2017,45(4):346-352.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM7012-10mM | 胆酸(98%, HPLC) | 10mM×0.2ml |
| SM7012-25mg | 胆酸(98%, HPLC) | 25mg |
| SM7012-100mg | 胆酸(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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