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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM4120-10mM | 粉防己碱(98%, HPLC) | 10mM×0.2ml | 87.00元 |
| SM4120-25mg | 粉防己碱(98%, HPLC) | 25mg | 135.00元 |
| SM4120-100mg | 粉防己碱(98%, HPLC) | 100mg | 459.00元 |
| 中文名 | 粉防己碱 |
| 英文名 | Tetrandrine |
| 中文别名 | 汉防己甲素 |
| 英文别名 | Hanfangchin A; NSC-77037; d-Tetrandrine |
| 来源 | 粉防己Stephania tetrandra S. Moore |
| 化合物类型 | 生物碱(Alkaloids)>异喹啉生物碱>双苄基异喹啉生物碱 |
| 化学式 | C38H42N2O6 |
| 分子量 | 622.75 |
| CAS号 | 518-34-3 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 7mg/ml (11.2 mM) |
| 溶液配制 | 10mg加入1.61ml DMSO，或者每6.23mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current. | ||||
| 信号通路 | - | ||||
| 靶点 | Ca2+ current | K+ current | ICa | - | - |
| IC50 | - | - | 10.1 μM | - | - |
| 体外研究 | The effects of Tetrandrine (NSC-77037), a bis-benzyl-isoquinoline alkaloid, on voltage-gated Ca2+ currents (ICa) and on Ca2+-activated K+ current (IK(Ca)) and channels in isolated nerve terminals of the rat neurohypophysis are investigated using patch-clamp techniques. The non-inactivating component of ICa is inhibited by external Tetrandrine (NSC-77037) in a voltage- and dose-dependent manner, with an IC50=10.1μM. Tetrandrine (NSC-77037) decreases the channel-open probability, within bursts, with an IC50=0.21 μM. To evaluate the effects of Tetrandrine on HCC cells, Huh7, HCCLM9 and Hep3B cells are treated with 0 (DMSO), 0.5, 1, 2 or 4 μM of Tetrandrine for 24 h. The cell proliferation assay indicates that Tetrandrine exhibits almost no effect on the inhibition of HCC cell proliferation at 0.5-2 μM. However, Tetrandrine (NSC-77037) inhibits HCC cell migration in a dose-dependent manner. Furthermore, a wound-healing and transwell assay shows that 2 μM Tetrandrine significantly inhibits HCC cell migration and invasion. | ||||
| 体内研究 | To evaluate the effect of Tetrandrine (NSC-77037) on the inhibition of tumor metastasis in vivo, HCCLM9 subcutaneous tumor xenograft models is established with athymic nude mice. When the tumor volume reach approximately 50 mm3, nude mice are orally administered vehicle or Tetrandrine (NSC-77037) (30 mg/kg) every other day for 37 days. Tetrandrine (NSC-77037) treatment inhibits tumor growth by reducing the tumor volume and weight. | ||||
| 临床实验 | NCT04308317: Corona Virus Disease 2019,COVID-19, Phase 4. | ||||
1.Wang G, et al. Pflugers Arch. 1992,421(6):558-65.
2.Zhang Z, et al. J Exp Clin Cancer Res. 2018,37(1):7.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4120-10mM | 粉防己碱(98%, HPLC) | 10mM×0.2ml |
| SM4120-25mg | 粉防己碱(98%, HPLC) | 25mg |
| SM4120-100mg | 粉防己碱(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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