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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM4076-10mM | 吴茱萸次碱(98%, HPLC) | 10mM×0.2ml | 77.00元 |
| SM4076-25mg | 吴茱萸次碱(98%, HPLC) | 25mg | 160.00元 |
| SM4076-100mg | 吴茱萸次碱(98%, HPLC) | 100mg | 544.00元 |
| 中文名 | 吴茱萸次碱 |
| 英文名 | Rutaecarpine |
| 中文别名 | - |
| 英文别名 | Rhetine; Rutecarpine |
| 来源 | 吴茱萸Euodia rutaecarpa (Juss.) Benth. |
| 化合物类型 | 生物碱(Alkaloids)>色氨吲哚类生物碱 |
| 化学式 | C18H13N3O |
| 分子量 | 287.32 |
| CAS号 | 84-26-4 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
DMSO: 50 mg/ml (174.02 mM); Water: < 0.1 mg/ml (insoluble) |
| 溶液配制 | 5mg加入1.74ml DMSO，或者每2.87mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM. | ||||
| 信号通路 | - | ||||
| 靶点 | COX-2 | COX-1 | - | - | - |
| IC50 | 0.28 μM | 8.7 μM | - | - | - |
| 体外研究 | Rutaecarpine has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. Rutaecarpine inhibits COX-2 and COX-1 dependent phases of PGD2 generation in BMMC in a concentration-dependent manner with an IC50 of 0.28 μM and 8.7 μM, respectively. It inhibits COX-2-dependent conversion of exogenous arachidonic acid to PGE2 in a dose-dependent manner by the COX-2-transfected HEK293 cells. | ||||
| 体内研究 | Rutaecarpine showed in vivo anti-inflammatory activity on rat l-carrageenan induced paw edema by intraperitoneal administration. Rutaecarpine significantly decreases the number of antibody-forming cells and causes weight decrease in spleen in a dose-dependent manner. In addition, rutaecarpine administered mice exhibit reduced splenic cellularity, decreased numbers of total T cells, CD4+ cells, CD8+ cells, and B cells in spleen. IL-2, interferon and IL-10 mRNA expressions are suppressed significantly by rutaecarpine treatment. The number of CD4+IL-2+ cells is reduced significantly following administration of mice with rutaecarpine. | ||||
| 临床实验 | N/A | ||||
1.Moon TC, et al. Inflamm Res. 1999,48(12):621-5.
2.Lee SH, et al. Molecules. 2008,13(2):272-300.
3.Jeon TW, et al. Toxicol Lett. 2006,164(2):155-66.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4076-10mM | 吴茱萸次碱(98%, HPLC) | 10mM×0.2ml |
| SM4076-25mg | 吴茱萸次碱(98%, HPLC) | 25mg |
| SM4076-100mg | 吴茱萸次碱(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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