微信在线咨询
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM4060-10mM | 青藤碱(98%, HPLC) | 10mM×0.2ml | 73.00元 |
| SM4060-25mg | 青藤碱(98%, HPLC) | 25mg | 84.00元 |
| SM4060-100mg | 青藤碱(98%, HPLC) | 100mg | 286.00元 |
| 中文名 | 青藤碱 |
| 英文名 | Sinomenine |
| 中文别名 | 汉防己碱 |
| 英文别名 | Cucoline; Kukoline |
| 来源 | 青藤Sinomenium acuturn (Thunb.) Rehd. et Wils. |
| 化合物类型 | 生物碱(Alkaloids)>吗啡烷型生物碱 |
| 化学式 | C19H23NO4 |
| 分子量 | 329.39 |
| CAS号 | 115-53-7 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
DMSO: 65 mg/ml (197.33 mM) Water: 10 mg/ml (30.36 mM) |
| 溶液配制 | 5mg加入1.52ml DMSO，或者每3.29mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor. | ||||
| 信号通路 | - | ||||
| 靶点 | NF-κB | μ-Opioid Receptor | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Cell viability gradually decreased with increasing Sinomenine concentration. The migration ability of MDA-MB-231 cells is significantly weakened by 0.25, 0.5, and 1 mM of Sinomenine treatment. The wound-healing assay reveals that 0.25 and 0.5 mM Sinomenine significantly suppress the healing of the wound. When the MDA-MB-231 cells are treated with 0.5 mM Sinomenine, the healing progress is about 50%, but in the group treated with 0.25 mM Sinomenine and the untreated control, the healing is about 80% and nearly 95%, respectively. The IB assay following inhibitor of NF-κB (IκB) antibody IP shows that the binding of NF-κB to IκB is inhibited by Sinomenine treatment in a dose-dependent manne. | ||||
| 体内研究 | Sinomenine (i.p.) produces antinociception in the hot plate and tail flick tests in male rats at 40 mg/kg, but not at lower doses (10 or 20 mg/kg). At 10 to 40 mg/kg Sinomenine does not produce any observable side effect such as sedation, allergy or motor impairments. At 80 mg/kg, Sinomenine is mildly sedative in rats. Antinociception is also seen mice at 60 min following 80 mg/kg i.p. Sinomenine, but not at lower doses (20 or 40 mg/kg), in the tail flick test. Sinomenine at 80 mg/kg i.p. does not produce any observable side effects in mice. I.p or p.o. Sinomenine at 40 or 80 mg/kg dose-dependently reduces mechanical hypersensitivity in nerve injured mice. I.p. Sinomenine at 40 mg/kg, but not lower doses or vehicle, significantly decreases mechanical and cold allodynia for up to 240 min without producing motor deficits or sedation. At doses of 10 to 40 mg/kg, Sinomenine dose-dependently increases the paw withdrawal threshold. In non-chronic constriction injury (CCI) healthy rats, Sinomenine at the dose range of 10 to 40 mg/kg does not change the immobility behavior in the forced swimming test. | ||||
| 临床实验 | N/A | ||||
1.Song L, et al. Biochem Biophys Res Commun. 2015,464(3):705-10.
2.Wang MH, et al. Neurosci Lett. 2008,443(3):209-12.
3.Gao T, et al. Eur J Pharmacol. 2013,721(1-3):5-11.
4.Zhu Q, et al. Sci Rep. 2014,4:7270.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4060-10mM | 青藤碱(98%, HPLC) | 10mM×0.2ml |
| SM4060-25mg | 青藤碱(98%, HPLC) | 25mg |
| SM4060-100mg | 青藤碱(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
微信在线咨询
