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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM4012-10mM | 辣椒素(95%, HPLC) | 10mM×0.2ml | 79.00元 |
| SM4012-25mg | 辣椒素(95%, HPLC) | 25mg | 180.00元 |
| SM4012-100mg | 辣椒素(95%, HPLC) | 100mg | 612.00元 |
| 中文名 | 辣椒素 |
| 英文名 | Nonivamide |
| 中文别名 | 合成辣椒素；诺香草胺；香草壬酰胺；合成辣椒碱 |
| 英文别名 | Pelargonic acid vanillylamide；Nonanoic acid vanillylamide；Pseudocapsaicin |
| 来源 | 辣椒Capsicum annuum L. |
| 化合物类型 | 生物碱(Alkaloids) |
| 化学式 | C17H27NO3 |
| 分子量 | 293.40 |
| CAS号 | 2444-46-4 |
| 纯度 | 95%, HPLC |
| 溶剂/溶解度 | DMSO : 100 mg/ml (340.83 mM) |
| 溶液配制 | 5mg加入1.70ml DMSO，或者每2.93mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Nonivamide is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound and a capsaicinoid. It is an amide of pelargonic acid and vanillylamine. It is present in chili peppers, but is commonly manufactured synthetically. It is more heat-stable than capsaicin. | ||||
| 信号通路 | - | ||||
| 靶点 | TRPV1 | - | - | - | - |
| IC50 | 1 μM | - | - | - | - |
| 体外研究 | Nonivamide, a synthetic derivate of natural capsaicin, has an effective antifouling activity. Capsaicin exhibits 4d-EC50 values of 5.5±0.5 mg/L, 23±2 mg/L, 6.9±0.2 mg/L, and 15.6±0.4 mg/L in static toxicity tests conducted using Pseudomonas putida, Lake Erie bacteria, Vibrio natriegens, and Vibrio parahaemolyticus, respectively. A significant growth inhibitory effect (p<0.01) is observed in the group treated with 1 mg/L of Nonivamide for 4 d, and the EC50 value (4 d-EC50) is 5.1 mg/L. Nonivamide treatment causes calcium release from the ER and altered the transcription of growth arrest- and DNA damage-inducible transcript 3 (GADD153), GADD45α, GRP78/BiP, ATF3, CCND1, and CCNG2) in a manner comparable with prototypical ER stress-inducing agents. ER calcium flux is evaluated by pretreating cells with 2.5 μM thapsigargin for 5 min followed by addition of 2.5 μM Nonivamide. Treatment of TRPV1-overexpressing cells with 2.5 μM Nonivamide produces marked increases in cytosolic calcium due to release of calcium from ER stores. Treatment of TRPV1-overexpressing cells with 1 μM Nonivamide causes an approximate 50% loss in cell viability after a 24-h period. BEAS-2B cells treated with 100 and 200 μM Nonivamide also exhibits a shift in the relative amount of EIF2α-P and an increase in the expression of GADD153 mRNA and protein. Treatment with Nonivamide reduces lipid accumulation to a similar extent as CAP; the effects are not different from the effects after CAP treatment at any of the tested concentrations. Compared to untreated control cells, treatment with Nonivamide decreases lipid accumulation by 5.34±1.03% (P<0.05) at 0.01 µM up to 10.4±2.47% (P<0.001) at 1 µM.Nonivamide is a agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | NCT01708915：Acute Low Back Pain，Phase 3；NCT02300311：Low Back Pain，Phase 3. | ||||
1.Zhou J, et al. Environ Toxicol Chem. 2013,32(4):802-9.
2.Thomas KC, et al. J Pharmacol Exp Ther. 2007,321(3):830-8.
3.Rohm B, et al. J Cell Biochem. 2015,116(6):1153-63.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4012-10mM | 辣椒素(95%, HPLC) | 10mM×0.2ml |
| SM4012-25mg | 辣椒素(95%, HPLC) | 25mg |
| SM4012-100mg | 辣椒素(95%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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