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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2211-10mM | 葛根素(98%, HPLC) | 10mM×0.2ml | 72.00元 |
| SM2211-25mg | 葛根素(98%, HPLC) | 25mg | 60.00元 |
| SM2211-100mg | 葛根素(98%, HPLC) | 100mg | 204.00元 |
| 中文名 | 葛根素 |
| 英文名 | Puerarin |
| 中文别名 | 葛根黄酮 |
| 英文别名 | 8-C-glucoside; 8-Glucopyranosyldaidzein; 8-Glucosyldaidzein |
| 来源 | 葛Pueraria lobata（Willd.）Ohwi |
| 化合物类型 | 黄酮类(Flavonoids)>异黄酮 |
| 化学式 | C21H20O9 |
| 分子量 | 416.38 |
| CAS号 | 3681-99-0 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 50 mg/ml (120.08 mM) |
| 溶液配制 | 5mg加入1.20ml DMSO，或者每4.16mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist. | ||||
| 信号通路 | NF-κB | ||||
| 靶点 | 5-HT2C Receptor | iNOS | COX-2 | CRP | I-κB |
| IC50 | - | - | - | - | - |
| 体外研究 | Puerarin inhibits the expression of LPS-induced iNOS, COX-2 and CRP proteins and also suppresses their mRNAs from RT-PCR experiments in RAW264.7 cells. The inhibition of iNOS, COX-2 and CRP expression is due to a dose-dependent inhibition of phosphorylation and degradation of I-κB, which resulted in the reduction of p65NF-κB nuclear translocation. The effect of puerarin-mediated inhibition of LPS-induced iNOS, COX-2 and CRP expression is attributed to suppressed NF-κB activation at the transcriptional level. Puerarin is a novel open-channel blocker of IK1, which may underlie the antiarrhythmic action of puerarin. Puerarin competes with barium, an open-channel blocker of IK1, to inhibit IK1 currents. | ||||
| 体内研究 | Both genistein and puerarin effectively alleviate hepatic damage induced by chronic alcohol administration through potential antioxidant, anti-inflammatory, or anti apoptotic mechanisms. However, genistein is more effective than puerarin in decreasing levels of malondialdehyde (1.05±0.0947 vs. 1.28±0.213 nmol/mg pro, p< 0.05), tumor necrosis factor α (3.12±0.498 vs. 3.82±0.277 pg/mg pro, p < 0.05), interleukin-6 (1.46±0.223 vs. 1.88±0.309 pg/mg pro, p < 0.05), whereas puerarin is more effective than genistein in ameliorating serum activities or levels of alanine transaminase (35.8±3.95 vs. 42.6±6.56 U/L, p < 0.05) and low-density lipoprotein cholesterol (1.12±0.160 vs. 1.55±0.150 mmol/L, p < 0.05). Early-stage renal damages can be significantly improved by puerarin, possibly via its suppression of ICAM-1 and TNF-α expression in diabetic rat kidneys. | ||||
| 临床实验 | NCT02254655: Rheumatoid Arthritis, Phase 2; NCT03016793: Alveolar Cleft Grafting, Phase 2; NCT03676296: Cardiovascular Disease Risk Factors, Phase 2; NCT03099590: Alcohol Drinking|Alcohol Use Disorder|Alcohol Abstinence, Phase 2. | ||||
1.Hu W, et al. Pharmacol Rep. 2011,63(3):781-9.
2.Zhang H, et al. Mol Cell Biochem. 2011,352(1-2):117-23.
3.Zhao L,et al. J Agric Food Chem. 2016,64(38):7291-7.
4.Pan X, et al. Med Sci Monit. 2015,21:2134-40.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2211-10mM | 葛根素(98%, HPLC) | 10mM×0.2ml |
| SM2211-25mg | 葛根素(98%, HPLC) | 25mg |
| SM2211-100mg | 葛根素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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