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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2191-10mM | 异鼠李素(98%, HPLC) | 10mM×0.2ml | 94.00元 |
| SM2191-5mg | 异鼠李素(98%, HPLC) | 5mg | 86.00元 |
| SM2191-25mg | 异鼠李素(98%, HPLC) | 25mg | 360.00元 |
| SM2191-100mg | 异鼠李素(98%, HPLC) | 100mg | 1224.00元 |
化学信息：
| 中文名 | 异鼠李素 |
| 英文名 | Isorhamnetin |
| 中文别名 | - |
| 英文别名 | Isorhamnetol; Quercetin 3′-methyl ether |
| 来源 | 沙棘Hippophae rhamnoides Linn. |
| 化合物类型 | 黄酮类(Flavonoids)>黄酮>黄酮醇 |
| 化学式 | C16H12O7 |
| 分子量 | 316.26 |
| CAS号 | 480-19-3 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/ml (316.20 mM) |
| 溶液配制 | 5mg加入1.58ml DMSO，或者每3.16mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K. | ||||
| 信号通路 | Akt/mTOR; MEK/ERK | ||||
| 靶点 | MEK1 | PI3K | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Isorhamnetin is a plant flavonoid that occurs in fruits and medicinal herbs. Isorhamnetin binds directly to MEK1 in an ATP-noncompetitive manner and to PI3-K in an ATP-competitive manner. In vitro and ex vivo kinase assay data show that Isorhamnetin inhibits the kinase activity of MAP/ERK kinase (MEK) 1 and PI3-K and the inhibition is due to direct binding with Isorhamnetin. Isorhamnetin inhibits the Akt/mTOR and MEK/ERK signaling pathways, and promotes the activity of the mitochondrial apoptosis signaling pathway. The inhibitory effects of Isorhamnetin on breast cancer cells are determined using the CCK-8 method. Isorhamnetin inhibits the proliferation of numerous breast cancer cells (IC50, ~10 µM), including MCF7, T47D, BT474, BT-549, MDA-MB-231 and MDA-MB-468, whereas less inhibitory activity is observed in the MCF10A normal breast epithelial cell line (IC50, 38 µM). | ||||
| 体内研究 | Photographic data shows that Isorhamnetin treatment suppresses tumor development in mice. The average volume of tumors in untreated mice increases over time and reaches a volume of 623 mm3 at 4 weeks post-inoculation; however, at this time, in mice treated with 1 or 5 mg/kg Isorhamnetin, the average tumor volume is only 280 or 198 mm3, respectively. At the end of the study, Isorhamnetin treatment (1 or 5 mg/kg) reduces tumor weight compared with the untreated control group. | ||||
| 临床实验 | N/A | ||||
1. Kim JE, et al. Cancer Prev Res (Phila). 2011,4(4):582-91.
2. Hu S, et al. Mol Med Rep. 2015,12(5):6745-51.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2191-10mM | 异鼠李素(98%, HPLC) | 10mM×0.2ml |
| SM2191-5mg | 异鼠李素(98%, HPLC) | 5mg |
| SM2191-25mg | 异鼠李素(98%, HPLC) | 25mg |
| SM2191-100mg | 异鼠李素(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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