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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2187-10mM | 异槲皮苷(98%, HPLC) | 10mM×0.2ml | 147.00元 |
| SM2187-5mg | 异槲皮苷(98%, HPLC) | 5mg | 168.00元 |
| SM2187-25mg | 异槲皮苷(98%, HPLC) | 25mg | 702.00元 |
| SM2187-100mg | 异槲皮苷(98%, HPLC) | 100mg | 2387.00元 |
化学信息：
| 中文名 | 异槲皮苷 |
| 英文名 | Isoquercitrin |
| 中文别名 | 异槲皮素 |
| 英文别名 | Quercetin 3-glucoside；Hirsutrin；Isoquercetin；Isoquercitroside |
| 来源 | 罗布麻Apocynum venetum L. |
| 化合物类型 | 黄酮类(Flavonoids)>黄酮>黄酮醇 |
| 化学式 | C21H20O12 |
| 分子量 | 464.38 |
| CAS号 | 482-35-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 19.23 mg/ml (41.41 mM) |
| 溶液配制 | 5mg加入1.08ml DMSO，或者每4.64mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies. | ||||
| 信号通路 | Nrf2/ARE | ||||
| 靶点 | NF-κB | NO2 | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Isoquercetin (Quercetin 3-glucoside; 5-20 μM; 24 hours) substantially reduces ethanol-induced cytotoxicity , protects hepatic cells against ethanol-stimulated liver injury. Isoquercetin (10 μM; pre-treat 1 hour) dramatically downregulates the levels of ethanol-induced iNOS protein expression in HepG2 cells. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | NCT02195232: Thromboembolism of Vein VTE in Colorectal Cancer|Thromboembolism of Vein in Pancreatic Cancer|Thromboembolism of Vein in Non-small Cell Lung Cancer, Phase 2|Phase 3. | ||||
1. Lee S, et al. J Food Biochem. 2019,43(11):e13002.
2. Tan C, et al. Am J Obstet Gynecol. 2018,219(2):197.e1-197.e8.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2187-10mM | 异槲皮苷(98%, HPLC) | 10mM×0.2ml |
| SM2187-5mg | 异槲皮苷(98%, HPLC) | 5mg |
| SM2187-25mg | 异槲皮苷(98%, HPLC) | 25mg |
| SM2187-100mg | 异槲皮苷(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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