碧云天生物技术-Staurosporine (PKC抑制剂)(S1883)

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试剂> 抑制剂激活剂等> PKC、钙离子及脂信号通路> PKC Signaling

Staurosporine (PKC抑制剂)

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产品编号: S1883

产品包装:0.5mg

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产品编号	产品名称	产品包装	产品价格
S1882	Staurosporine (PKC抑制剂)	0.1mg	612.00元
S1883	Staurosporine (PKC抑制剂)	0.5mg	1918.00元

Staurosporine，是一种可以通透细胞膜的蛋白激酶C(PKC)抑制剂，IC50达到0.7nM。在浓度较高时(1-20nM)，可以抑制
CDK1/cyclin B，CDK2/cyclin A，CDK4/cyclin D，CDK/p25，GSK-3β，PKA、PKG和CAMKII等蛋白激酶；在50-100nM，可以促进神经突起的生长(Neurite outgrowth)；在0.2-1μM，可以诱导细胞凋亡。Staurosporine还可以抑制肿瘤细胞中VEGF的上调。
Staurosporine分子量为466.53，分子式为C₂₈H₂₆N₄O₃，CAS Number：62996-74-1。本产品为进口分装，纯度大于98%。
Staurosporine可溶于DMSO和DMF，微溶于氯仿和甲醇，不溶于水。
本Staurosporine用DMSO配制，浓度为1mM，体积约为0.21ml×5，经过滤除菌可直接用于细胞培养。
包装清单：

产品编号	产品名称	包装
S1883	Staurosporine(PKC抑制剂,1mM)	S1882×5管
—	说明书	1份

保存条件：
-20℃避光保存。-70℃避光保存更佳。
注意事项：
本产品对人体有毒，操作时请特别小心，并注意有效防护以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：
1. Staurosporine常见使用浓度范围为10-200nM。具体的最佳工作浓度请参考相关文献，或根据实验目的，以及所培养的特定细胞和组织，通过实验进行摸索和优化。

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PKC Signaling

使用本产品的文献：

1. Lv QY, Wan B, Guo LH, Zhao L, Yang Y.

In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: apoptosis and immune cell dysfunction.

Chemosphere. 2015 Feb;120:621-30. (IF 5.778)

2. Chen D, Xiong Y, Lin Y, Tang Z, Wang J, Wang L, Yao J.

Capsaicin alleviates abnormal intestinal motility through regulation of enteric motor neurons and MLCK activity: Relevance to intestinal motility disorders.

Mol Nutr Food Res. 2015 Aug;59(8):1482-90. (IF 5.309)

3. Chen X, Tang W, Liu S, Yu L, Chen Z.

Thioredoxin-1 phosphorylated at T100 is needed for its anti-apoptotic activity in HepG2 cancer cells.

Life Sci. 2010;87(7-8):254-60. (IF 3.647)

4. Wang C, Li YJ, Zheng YQ, Feng B, Liu Y, Cao JM.

Glucocorticoid decreases airway tone via a nongenomic pathway.

RESP PHYSIOL NEUROBI. 2012 Jul 31;183(1):10-4. (IF 1.591)

5. Mao YF, Zhang YL, Yu QH, Jiang YH, Wang XW, Yao Y, Huang JL.

Chronic restraint stress aggravated arthritic joint swell of rats through regulating nitric oxide production.

NITRIC OXIDE-BIOL CH. 2012 Oct 15;27(3):137-42. (IF 3.311)

6. Yu W, Wang M, Zhang H, Quan Y, Zhang Y.

Expression and Functional Analysis of Storage Protein 2 in the Silkworm, Bombyx mori.

Int J Genomics. 2013;2013:145450. (IF 2.414)

7. Jiang S, Zhao L, Lu Y, Wang M, Chen Y, Tao D, Liu Y, Sun H, Zhang S, Ma Y.

Piwil2 inhibits keratin 8 degradation through promoting p38-induced phosphorylation to resist Fas-mediated apoptosis.

Mol Cell Biol. 2014 Nov;34(21):3928-38. (IF 3.611)

8. Wang Z, Zhang X, Tian H, Wang W, Ru S.

Effects of monocrotophos pesticide on steroidogenesis and transcription of steroidogenic enzymes in rainbow trout RTG-2 cells involving the protein kinase A signal pathway.

Toxicol In Vitro. 2015 Feb;29(1):155-61. (IF 2.959)

9. Lv D, Shen Y, Peng Y, Liu J, Miao F, Zhang J.

Neuronal MHC Class I Expression Is Regulated by Activity Driven Calcium Signaling.

PLoS One. 2015 Aug 11;10(8):e0135223. (IF 2.74)

10. Jiang H, Tong Y, Yan D, Jia S, Ostenson CG, Chen Z.

The Soybean Peptide Vglycin Preserves the Diabetic β-cells through Improvement of Proliferation and Inhibition of Apoptosis.

SCI REP-UK. 2015 Oct 29;5:15599. (IF 3.998)

11. Tian X, Chang L, Ma G, Wang T, Lv M, Wang Z, Chen L, Wang Y, Gao X, Zhu Y.

Delineation of platelet activation pathway of Scutellarein revealed its intracellular target as Protein Kinase C.

Biol Pharm Bull. 2016;39(2):181-91. (IF 1.863)

12. Tian X, Chang L, Ma G, Wang T, Lv M, Wang Z, Chen L, Wang Y, Gao X, Zhu Y.

Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein KinaseC.

Biol Pharm Bull. 2016;39(2):181-91. (IF 1.863)

13. Gan T, Wang Y, Zhao M, Wu J, Yang J, Peng S.

5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy ofdesigning drug to block lung metastasis of tumors.

DRUG DES DEV THER. 2016 Feb 16;10:711-21. (IF 3.216)

14. Yu ZL, Li DQ, Huang XY, Xing X, Yu RQ, Li Z, Li ZB.

Lysophosphatidic acid upregulates connective tissue growth factor expression in osteoblasts through theGPCR/PKC and PKA pathways.

Int J Mol Med. 2016 Feb;37(2):468-74. (IF 3.098)

15. Tan ST, Liu SY, Wu B.

TRIM29 Overexpression Promotes Proliferation and Survival of Bladder Cancer Cells through NF-κBSignaling.

Cancer Res Treat. 2016 Oct;48(4):1302-1312. (IF 3.761)

16. Zhao J, Zhang Y, Zhao J, Wang C, Mao J, Li T, Wang X, Nie X, Jiang S, Wu Q.

2,3,7,8-tetrachlorodibenzo-p-dioxin exposure influence the expression of glutamate transporter GLT-1 in C6glioma cells via the Ca(2+) /protein kinase C pathway.

J Appl Toxicol. 2016 Nov;36(11):1409-17. (IF 2.997)

17. Ma T, Chen X, Ouyang H, Liu X, Ouyang T, Peng Z, Yang X, Chen F, Pang D, Bai J, Ren L.

HMGCR inhibits the early stage of PCV2 infection, while PKC enhances the infection at the latestage.

Virus Res. 2017 Feb 2;229:41-47. (IF 2.934)

18. Ma T, Chen X, Ouyang H, Liu X, Ouyang T, Peng Z, Yang X, Chen F, Pang D, Bai J, Ren L.

HMGCR inhibits the early stage of PCV2 infection, while PKC enhances the infection at the late stage.

Virus Res. 2017 Feb 2;229:41-47. (IF 2.934)

19. Luo L, Xi C, Xu T, Zhang G, Qun E, Zhang W.

Muscarinic receptor mediated signaling pathways in hepatocytes from CCL4 - induced liverfibrotic rat.

Eur J Pharmacol. 2017 Jul 15;807:109-116. (IF 3.263)

20. Tai H, Wang X, Zhou J, Han X, Fang T, Gong H, Huang N, Chen H, Qin J, Yang M, Wei X, Yang L, Xiao H.

Protein kinase Cβ activates fat mass and obesity-associated protein by influencing its ubiquitin/proteasome degradation.

FASEB J. 2017 Oct;31(10):4396-4406. (IF 4.966)

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