碧云天生物技术-总一氧化氮检测试剂盒(S0023)

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试剂> 信号转导> 信号小分子检测> 一氧化氮相关

总一氧化氮检测试剂盒

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产品编号: S0023

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产品编号	产品名称	产品包装	产品价格
S0023	总一氧化氮检测试剂盒	50次	588.00元
S0024	总一氧化氮检测试剂盒	200次	1850.00元

总一氧化氮检测试剂盒(Total Nitric Oxide Assay Kit, 即Nitrate/Nitrite Assay Kit)采用了硝酸盐还原酶(Nitrate reductase)还原硝酸盐(nitrate)为亚硝酸盐(nitrite)，然后通过经典的Griess reagent检测亚硝酸盐，从而测定出总一氧化氮。一氧化氮本身极不稳定，在细胞内很快代谢为硝酸盐(Nitrate)和亚硝酸盐(Nitrite)，通过上述方法检测出硝酸盐和亚硝酸盐的总量，就可以推算出总的一氧化氮的量。
本试剂盒采用了NADPH依赖性硝酸盐还原酶(NADPH dependent nitrate reductase)。高浓度的NADPH会干扰后续的检测，消除NADPH的一种常用方法就是使用Lactate dehydrogenase(LDH)清除NADPH。本试剂盒采用了LDH清除NADPH的方法，使检测结果更加准确。
对亚硝酸盐的检测下限达到2微摩尔/升，在2-80微摩尔/升的范围内有很好的线性关系。浓度过高的样品可以适当稀释后再进行检测。
样品范围广，可以检测细胞裂解液、组织裂解液、细胞或组织的培养液、血清、血浆或尿液等中一氧化氮的含量。酚红和10%血清对测定无明显干扰。
样品需要量少。根据样品中一氧化氮的浓度不同，仅需0-60微升样品。
检测速度快，仅需约80分钟即可完成检测。
本试剂盒采用了间接的一氧化氮检测方法，如需检测细胞内实际的一氧化氮水平，可以采用碧云天生产的DAF-FM DA(NO荧光探针)(S0019)。
包装清单：

产品编号	产品名称	包装
S0023-1	样品稀释液	15ml
S0023-2	NADPH	5mg
S0023-3	FAD	550μl
S0023-4	Nitrate Reductase	250μl
S0023-5	LDH Buffer	550μl
S0023-6	LDH	500μl
S0023-7	NaNO₂(1M)	1ml
S0023-8	Griess Reagent I	3ml
S0023-9	Griess Reagent II	3ml
—	说明书	1份

保存条件：
-20℃保存，一年有效。NADPH，Nitrate Reductase，NaNO₂ (1M)，Griess Reagent I和Griess Reagent II需避光保存。NADPH配制成溶液后必须分装并-70℃保存。
注意事项：
RPMI 1640等含有较高浓度硝酸盐的培养液容易对本试剂盒的检测产生干扰，请尽量避免。必需使用RPMI 1640培养液时，在检测一氧化氮前必需先换成其他适当培养液例如DMEM、MEM、F12等，或换成HBSS或PBS等。
推荐选购碧云天生产的细胞与组织裂解液(一氧化氮检测用)(S3090)用于细胞或组织样品的裂解。也可以自行选择适当方式制备细胞或组织样品的裂解液用于总一氧化氮的检测，但需注意自行选择的方式可能会干扰试剂盒检测时的酶反应而影响检测效果。检测细胞或组织的培养液、血清、血浆或尿液中的总一氧化氮含量时，不需要选购S3090。S3090裂解获得的样品还可以用于蛋白浓度的检测以及Western印迹检测，但需注意S3090中不含蛋白酶和磷酸酯酶抑制剂。
检测反应必须避光进行。
由于检测过程中有还原反应，凡是影响还原反应的氧化或还原试剂要注意避免，例如常用的还原剂DTT和巯基乙醇。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：
1. 样品处理：
含有高浓度蛋白的样品例如血清、含有高浓度血清的细胞培养液，在加入Griess Reagent I后可能会产生沉淀。可以取50微升样品，加入50微升Griess Reagent I进行测试，观察是否产生沉淀。如果产生沉淀，则可以把样品沸水浴加热5分钟，以变性蛋白，然后12,000g离心5分钟，取上清用于后续的测定。对于细胞或组织样品可以用碧云天生产的细胞与组织裂解液(一氧化氮检测用)(S3090)进行裂解。对于尿液样品，通常需要用水稀释10-50倍后检测。不宜使用肝素抗凝的血浆，肝素抗凝的血浆在和Griess Reagent反应时会产生沉淀。
2. 稀释标准品：
用制备或稀释样品时所使用的溶液把1M NaNO₂稀释成2、5、10、20、40、60、80微摩尔/升。例如样品为使用S3090裂解获得的细胞裂解液，则宜使用S3090稀释标准品；样品为细胞培养液，则用该培养液稀释标准品。如果样品为血清，则可以使用本试剂盒提供的样品稀释液(S0023-1)或简单地使用PBS、生理盐水等适当溶液稀释标准品。稀释的标准品宜现配现用，不宜冻存后使用。
3. 试剂的准备：
a. 加约1ml双蒸水或Milli-Q级纯水至5mg NADPH中，颠倒混匀溶解后，再用双蒸水或Milli-Q级纯水定容至3ml，配制成2mM NADPH，除立即使用的部分外，其余NADPH溶液必须立即分装后-70℃冻存。
b. FAD已经配制在适当溶液中。FAD可以适当分装后-20℃或-70℃保存。
c. Nitrate Reductase和LDH在临用前取出，并放置在冰浴上使用(注意在使用完毕后立即-20℃保存)，试剂盒中的其余各种试剂在溶解后保存在冰浴上。Griess Reagent I和Griess Reagent II 在使用前需达到室温。
4. 参考下表依次加入标准品、样品和检测试剂并进行相应检测：

	空白对照	标准品	样品
标准品	－	60微升	－
样品	－	－	x微升
用于样品稀释的溶液	60微升	－	(60-x)微升
NADPH(2mM)	5微升	5微升	5微升
FAD	10微升	10微升	10微升
Nitrate Reductase	5微升	5微升	5微升
混匀后，37℃孵育30分钟
LDH Buffer	10微升	10微升	10微升
LDH	10微升	10微升	10微升
混匀后，37℃孵育30分钟
Griess Reagent I	50微升	50微升	50微升
Griess Reagent II	50微升	50微升	50微升
混匀后，室温(20-30℃)孵育10分钟后测定A540

注意事项：
a. 反应必须避光进行。如果使用96孔板进行检测，可以使用铝箔纸包裹96孔板进行避光。
b. 样品的用量上限为60微升，血清、血浆或组织匀浆液通常使用40微升就足够了。样品不足60微升时，不同样品之间的体积需要保持一致，体积不足的部分用制备或稀释样品时所使用的溶液补足。标准品可以参考上表使用60微升。
c. 可以同时设置加入200微升水或PBS的2-3个孔为阴性对照，这2-3个孔仅仅加入水或PBS，不再加入任何其他试剂。
d. 第一部分37℃孵育30分钟后，直接参考上表依次加入LDH Buffer和LDH，并进行后续孵育。
e. 第二部分37℃孵育30分钟后，直接参考上表依次加入Griess Reagent I和Griess Reagent II。加入Griess Reagent I后需要轻轻混匀。
f. 每次混匀后，可以1000-3000g离心数秒，把液体沉淀到管底。同时需避免各检测孔中产生气泡，以免气泡干扰检测结果。
g. 检测时，如无540nm滤光片，520-560nm的滤光片也可以使用。如无酶标仪或合适的滤光片，也可以通过数码相机拍照后在适当图形软件中进行定量分析，并确定样品中一氧化氮的浓度。拍照比色时标准品需要更为精细的浓度梯度。
5. 根据标准品曲线计算出样品中一氧化氮的浓度。
6. 标准曲线示例见图1，供参考。实际测定时，由于反应条件、试剂盒批次的不同等因素，会导致检测结果与示例数据存在一定差异。
常见问题：
1．检测结果标准曲线良好，但样品的吸光度很低，和空白对照接近。
标准曲线良好说明检测方法和检测试剂盒基本上没有问题，样品吸光度低说明样品中一氧化氮含量很低。可以采取的办法是：(1)加大样品和标准品的使用量至60微升，其余试剂用量不变。(2)把整个检测体系每种试剂的用量加大50%，这样可以使检测灵敏度增加约50%。如果上述方法还不能解决问题，可以考虑浓缩样品，即一方面在收集样品的时候尽量使一氧化氮的浓度保持得较高(例如裂解细胞时采用较小体积的裂解液)，另一方面可以考虑用真空干燥或真空冷冻干燥的方法浓缩样品。对于培养的细胞，通常上清液测定出来的吸光度相对较低，而细胞裂解液测定出来的吸光度会稍高一些。
2．检测时发现每个样品的吸光度都非常高。
在使用RPMI 1640培养液时会发生这种情况。因为RPMI 1640培养液中含有高浓度的硝酸盐从而会使样品检测出来的吸光度都非常高。其他含有高浓度硝酸盐的试剂也会产生类似情况，影响氧化还原反应的试剂也可能产生类似干扰。使用过程中避免使用RPMI 1640等可能导致干扰检测的试剂即可。

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37. Jiang Q, Zhou Z, Wang L, Shi X, Wang J, Yue F, Yi Q, Yang C, Song L.

The immunomodulation of inducible nitric oxide in scallop Chlamys farreri.

FISH SHELLFISH IMMUN. 2013 Jan;34(1):100-8. (IF 3.298)

38. Zhong XN, Wang HH, Lu ZQ, Dai YQ, Huang JH, Qiu W, Shu YQ, Xu W, Cheng C, Hu XQ.

Effects of Naoxintong on atherosclerosis and inducible nitric oxide synthase expression in atherosclerotic rabbit.

CHINESE MED J-PEKING. 2013 Mar;126(6):1166-70. (IF 1.585)

39. Jin LF, Wang YY, Zhang ZD, Yuan YM, Hu YR, Wei YF, Ni J.

Cytotoxicity and genome-wide microarray analysis of intestinal smooth muscle cells in response to hexavalent chromium induction.

动物学研究. 2013 Jun 8;34(3):E93-E100.

40. Song Y, Zhao XP, Song K, Shang ZJ.

Ephrin-A1 is up-regulated by hypoxia in cancer cells and promotes angiogenesis of HUVECs through a coordinated cross-talk with eNOS.

PLoS One. 2013 Sep 9;8(9):e74464. (IF 2.74)

41. Zhang J, Niu N, Li B, McNutt MA.

Neuron-derived IgG protects neurons from complement-dependent cytotoxicity.

J Histochem Cytochem. 2013 Dec;61(12):869-79. (IF 2.187)

42. Jiang XS, Ni YQ, Liu TJ, Zhang M, Jiang R, Xu GZ.

Generation and characterization of immortalized rat retinal microglial cell lines.

J Neurosci Res. 2014 Apr;92(4):424-31. (IF 4.699)

43. Wang T, Sun P, Chen L, Huang Q, Chen K, Jia Q, Li Y, Wang H.

Cinnamtannin D-1 protects pancreatic β-cells from palmitic acid-induced apoptosis by attenuating oxidative stress.

J AGR FOOD CHEM. 2014 Jun 4;62(22):5038-45. (IF 4.192)

44. Cao Q, Jiang Y, Shi J, Xu C, Liu X, Yang T, Fu P, Niu T.

Artemisinin inhibits the proliferation, migration, and inflammatory reaction induced by tumor necrosis factor-α in vascular smooth muscle cells through nuclear factor kappa B pathway.

J Surg Res. 2015 Apr;194(2):667-78. (IF 1.841)

45. Li YH, Xu Q, Xu WH, Guo XH, Zhang S, Chen YD.

Mechanisms of protection against diabetes-induced impairment of endothelium-dependent vasorelaxation by Tanshinone IIA.

BBA-BIOMEMBRANES. 2015 Apr;1850(4):813-23. (IF 3.411)

46. Yuan C, Zhang H, Wang W, Li Y, Yan R, Xu L, Song X, Li X.

Transmembrane protein 63A is a partner protein of Haemonchus contortus galectin in the regulation of goat peripheral blood mononuclear cells.

PARASITE VECTOR. 2015 Apr 9;8:211. (IF 2.824)

47. Zhao Q, Zhang J, Wang H.

PGC-1α overexpression suppresses blood pressure elevation in DOCA-salt hypertensive mice.

BIOSCIENCE REP. 2015 May 21;35(3). (IF 2.942)

48. Wang ZC, Liu H, Bai YG, Yu JW, Zhang HJ, Cheng YP, Bao JX, Ren XL, Ma HZ, Ma J.

28-Day hindlimb unweighting reduces expression of Rho kinase and inhibits its effects in femoral artery of rat.

J Physiol Biochem. 2015 Jun;71(2):205-16. (IF 2.952)

49. Liu XB, Yang BX, Zhang L, Lu YZ, Gong MH, Tian JK.

An in vivo and in vitro assessment of the anti-inflammatory, antinociceptive, and immunomodulatory activities of Clematis terniflora DC. extract, participation of aurantiamide acetate.

J Ethnopharmacol. 2015 Jul 1;169:287-94. (IF 3.69)

50. Zhao B, Zhou B, Bao L, Yang Y, Guo K.

Alpha-Tomatine Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated Macrophages.

Inflammation. 2015 Oct;38(5):1769-76. (IF 3.212)

51. Tian X, Zhao L, Song X, Yan Y, Liu N, Li T, Yan B, Liu B.

HSP27 Inhibits Homocysteine-Induced Endothelial Apoptosis by Modulation of ROS Production andMitochondrial Caspase-Dependent Apoptotic Pathway.

Biomed Res Int. 2016;2016:4847874. (IF 2.276)

52. Yao J, Zou Z, Wang X, Ji X, Yang J.

Pinoresinol Diglucoside Alleviates oxLDL-Induced Dysfunction in Human Umbilical Vein Endothelial Cells.

EVID-BASED COMPL ALT. 2016;2016:3124519. (IF 1.813)

53. Zhang ZB, Ruan CC, Chen DR, Zhang K, Yan C, Gao PJ.

Activating transcription factor 3 SUMOylation is involved in angiotensin II-induced endothelial cellinflammation and dysfunction.

J Mol Cell Cardiol. 2016 Mar;92:149-57. (IF 4.133)

54. Li P, Zhang L, Zhang M, Zhou C, Lin N.

Uric acid enhances PKC-dependent eNOS phosphorylation and mediates cellular ER stress: A mechanismfor uric acid-induced endothelial dysfunction.

Int J Mol Med. 2016 Apr;37(4):989-97. (IF 3.098)

55. Liu J, Zhang W, Shi H, Yang K, Wang G, Wang P, Ji J, Chu PK.

In situ plasma fabrication of ceramic-like structure on polymeric implant with enhanced surface hardness,cytocompatibility and antibacterial capability.

J Biomed Mater Res A. 2016 May;104(5):1102-12. (IF 3.525)

56. Gadahi JA, Yongqian B, Ehsan M, Zhang ZC, Wang S, Yan RF, Song XK, Xu LX, Li XR.

Haemonchus contortus excretory and secretory proteins (HcESPs) suppress functions of goat PBMCs invitro.

ONCOTARGET. 2016 Jun 14;7(24):35670-35679. (IF 5.168)

57. Li Y, Yuan C, Wang L, Lu M, Wang Y, Wen Y, Yan R, Xu L, Song X, Li X.

Transmembrane protein 147 (TMEM147): another partner protein of Haemonchus

PARASITE VECTOR. 2016 Jun 23;9(1):355. (IF 2.824)

58. Zhou G, Shi QS, Huang XM, Xie XB.

Comparison of transcriptomes of wild-type and isothiazolone-resistant Pseudomonas aeruginosa by usingRNA-seq.

Mol Biol Rep. 2016 Jun;43(6):527-40. (IF 1.402)

59. Lu J, Kan S, Zhao Y, Zhang W, Liu J.

Novel naproxen/esomeprazole magnesium compound pellets based on acid-independent mechanism: invitro and in vivo evaluation.

Drug Dev Ind Pharm. 2016 Sep;42(9):1495-503. (IF 2.365)

60. Linghu K, Lin D, Yang H, Xu Y, Zhang Y, Tao L, Chen Y, Shen X.

Ameliorating effects of ,8-cineole on LPS-induced human umbilical vein endothelial cell injury bysuppressing NF-κB signaling in vitro.

Eur J Pharmacol. 2016 Oct 15;789:195-201. (IF 3.263)

61. Ren Y, Tao S, Zheng S, Zhao M, Zhu Y, Yang J, Wu Y.

Salvianolic acid B improves vascular endothelial function in diabetic rats with blood glucose fluctuations viasuppression of endothelial cell apoptosis.

Eur J Pharmacol. 2016 Nov 15;791:308-315. (IF 3.263)

62. Gao Y, Wang W, Cao J, Wang F, Geng Y, Cao J, Xu X, Zhou J, Liu P, Zhang S.

Upregulation of AUF1 is involved in the proliferation of esophageal squamous

Int J Oncol. 2016 Nov;49(5):2001-2010. (IF 3.899)

63. Sun X, Jiao X, Ma Y, Liu Y, Zhang L, He Y, Chen Y.

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical veinendothelial cells via activating ROS-TXNIP-NLRP3 inflammasome.

BIOCHEM BIOPH RES CO. 2016 Dec 2;481(1-2):63-70. (IF 2.985)

64. Gadahi JA, Li B, Ehsan M, Wang S, Zhang Z, Wang Y, Hasan MW, Yan R, Song X, Xu L, Li X.

Recombinant Haemonchus contortus 24 kDa excretory/secretory protein (rHcES-24) modulate the immunefunctions of goat PBMCs in vitro.

ONCOTARGET. 2016 Dec 20;7(51):83926-83937. (IF 5.168)

65. Gadahi JA, Ehsan M, Wang S, Zhang Z, Wang Y, Yan R, Song X, Xu L, Li X.

Recombinant protein of Haemonchus contortus 14-3-3 isoform 2 (rHcftt-2) decreased the production of IL-4and suppressed the proliferation of goat PBMCs in vitro.

Exp Parasitol. 2016 Dec;171:57-66. (IF 1.69)

66. Li J, Geng XY, Cong XL.

Corrigendum to "PGC-1α ameliorates AngiotensinII-induced eNOS dysfunction in human

VASC PHARMACOL. 2016 Dec;87:248. (IF 4.152)

67. Yan Y, Du Y, Zheng H, Wang G, Li R, Chen J, Li K.

NS1 of H7N9 Influenza A Virus Induces NO-Mediated Cellular Senescence in Neuro2a Cells.

CELL PHYSIOL BIOCHEM. 2017;43(4):1369-1380. (IF 5.5)

68. Wang Z, Lv Q, Liu H, Wu Y, Bai Y, Cheng Y, Su Y, Cai Y, Yu J, Ma J, Bao J.

Caveolae Depletion Contributes to Vasorelaxant Effects of Chenodeoxycholic Acid.

CELL PHYSIOL BIOCHEM. 2017;42(3):1013-1024. (IF 5.5)

69. Guo Q, Xu L, Li H, Sun H, Liu J, Wu S, Zhou B.

Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidativestress and endoplasmic reticulum stress.

Lipids Health Dis. 2017 Jan 31;16(1):25. (IF 2.906)

70. Wei SJ, Cheng L, Liang ES, Wang Q, Zhou SN, Xu H, Hui LH, Ge ZM, Zhang MX.

Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aorticatherogenesis through downregulation of arginase II.

CLIN EXP PHARMACOL P . 2017 Jan;44(1):114-122. (IF 2.092)

71. Liu C, Hao Y, Huang J, Li H, Yang Z, Zeng Y, Liu J, Li R.

Ghrelin accelerates wound healing in combined radiation and wound injury in mice.

Exp Dermatol. 2017 Feb;26(2):186-193. (IF 3.368)

72. Guo J, Wang Y, Wang J, Zhang J, Fang J.

Radiosensitization of oral tongue squamous cell carcinoma by nanosecond pulsed electric fields (nsPEFs).

Bioelectrochemistry. 2017 Feb;113:35-41. (IF 4.722)

73. Huang Q, Wang T, Wang HY.

Ginsenoside Rb2 enhances the anti-inflammatory effect ofω-3 fatty acid in LPS-stimulatedRAW264.7 macrophages by upregulating GPR120 expression.

Acta Pharmacol Sin. 2017 Feb;38(2):192-200. (IF 5.064)

74. Li XH, Xue WL, Wang MJ, Zhou Y, Zhang CC, Sun C, Zhu L, Liang K, Chen Y, Tao BB, Tan B, Yu B, Zhu YC.

H2S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3pexpression.

SCI REP-UK. 2017 Mar 21;7:44807. (IF 3.998)

75. Chen XH, Liu SR, Peng B, Li D, Cheng ZX, Zhu JX, Zhang S, Peng YM, Li H, Zhang TT, Peng XX.

Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens.

Front Immunol. 2017 Mar 6;8:207. (IF 5.085)

76. Ehsan M, Gao W, Gadahi JA, Lu M, Liu X, Wang Y, Yan R, Xu L, Song X, Li X.

Arginine kinase from Haemonchus contortus decreased the proliferation and increased the apoptosis of goat PBMCs in vitro.

PARASITE VECTOR. 2017 Jun 26;10(1):311. (IF 2.824)

77. Qing L, Ariyadewa DK, Yi H, Wang Y, Zhou Q, Xu W.

Skin Lesions in Swine with Decompression Sickness: Clinical Appearance and Pathogenesis.

Front Physiol. 2017 Jul 25;8:540. (IF 3.367)

78. Liu X, Ma Q, Sun X, Lu M, Ehsan M, Hasan MW, Xu L, Yan R, Song X, Li X.

Effects of Recombinant Toxoplasma gondii Citrate Synthase Ionthe Cellular Functions of MurineMacrophages In vitro.

Front Microbiol. 2017 Jul 21;8:1376. (IF 4.235)

79. Chen P, Gao H, Lu Y, Nie H, Liu Z, Zhao Y, Fan N, Zou Q, Dai Y, Tang A, Hara H, Cai Z, Cooper DKC, Lai L, Mou L.

Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase,and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum-relevance to xenotransplantation.

Cell Biol Int. 2017 Jul;41(7):798-808. (IF 2.571)

80. Jiang J, Gan Z, Li Y, Zhao W, Li H, Zheng JP, Ke Y.

REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles ofthe eNOS/NO/cGMP pathway and supplementation with L-arginine.

PLoS One. 2017 Aug 15;12(8):e0182746. (IF 2.74)

81. Hou N, Jiang N, Zou Y, Piao X, Liu S, Li S, Chen Q.

Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance.

Front Microbiol. 2017 Aug 2;8:1431. (IF 4.235)

82. Lu M, Tian X, Yang X, Yuan C, Ehsan M, Liu X, Yan R, Xu L, Song X, Li X.

TheN-and C-terminal carbohydrate recognition domains of Haemonchus contortus galectin bind to distinct receptors of goat PBMC and contribute differently to its immunomodulatory functions in host-parasite interactions.

PARASITE VECTOR. 2017 Sep 5;10(1):409. (IF 2.824)

83. Shang Q, Bao L, Guo H, Hao F, Luo Q, Chen J, Guo C.

Contribution of glutaredoxin-1 to S-glutathionylation of endothelial nitric oxide synthase for mesenteric nitric oxide generation in experimental necrotizing enterocolitis.

Transl Res. 2017 Oct;188:92-105. (IF 5.411)

84. Long Y, Huang C, Wu J, Cheng JN, Liang GN, Jiang CX, Wan Q.

2,3',4,4',5-Pentachlorobiphenyl impairs insulin-induced NO production partly through excessiveROS production in endothelial cells.

TOXICOL MECH METHOD. 2017 Oct;27(8):592-597. (IF 2.295)

85. Gadahi JA, Ehsan M, Wang S, Zhang Z, Yan R, Song X, Xu L, Li X.

Recombinant protein of Haemonchus contortus small GTPase ADP-ribosylation factor 1 (HcARF1) modulate the cell mediated immune response in vitro.

ONCOTARGET. 2017 Nov 26;8(68):112211-21. (IF 5.168)

86. Qiu Y, Sui X, Cao S, Li X, Ning Y, Wang S, Yin L, Zhi X.

Steroidogenic Acute Regulatory Protein (StAR) Overexpression Reduces Inflammation and Insulin Resistance in Obese Mice.

J Cell Biochem. 2017 Nov;118(11):3932-3942. (IF 4.237)

87. Zheng Y, Wu Z, Yi F, Orange M, Yao M, Yang B, Liu J, Zhu H

By Activating Akt/eNOS Bilobalide B Inhibits Autophagy and Promotes Angiogenesis Following Focal Cerebral Ischemia Reperfusion.

CELL PHYSIOL BIOCHEM. 2018;47(2):604-616. (IF 5.5)

88. Li H, Chen LP, Wang T, Wang SG, Liu JH.

Calpain inhibition improves erectile function in diabetic mice via upregulating endothelial nitricoxide synthase expression and reducing apoptosis.

Asian J Androl. 2018 Jan 9. (IF 2.448)

89. Zhu BB, Wang H, Chi YF, Wang YM, Yao XM, Liu S, Qiu H, Fang J, Yin PH, Zhang XM, Peng W.

Protective effects of probucol on Ox-LDL-induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells via LOX 1/ROS/MAPK signaling.

Mol Med Rep. 2018 Jan;17(1):1289-1296. (IF 2.1)

90. Mao J, Hu X, Pang P, Zhou B, Zhang Y, Li D, Shan H.

Establishment ofa CRISPR/Cas9-Mediated Cysltr1 Knockout Mouse Model and iTRAQ-BasedProteomic Analysis.

PROTEOM CLIN APPL. 2018 Jan 26. (IF 2.489)

91. He SW, Wang GH, Yue B, Zhou S, Zhang M.

TO17:A teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum, Sciaenops ocellatus.

FISH SHELLFISH IMMUN. 2018 Jan;72:639-645. (IF 3.298)

92. Ma LL, Li Y, Yin PP, Kong FJ, Guo JJ, Shi HT, Zhu JB, Zou YZ, Ge JB.

Hypertrophied myocardium is vulnerable to ischemia/reperfusion injury and refractory to rapamycin-induced protection dueto increased oxidative/nitrative stress.

CLIN SCI. 2018 Jan 11;132(1):93-110. (IF 5.223)

93. Zhang B, Zhang Z, Ji H, Shi H, Chen S, Yan D, Jiang X, Shi B

Grape seed proanthocyanidin extract alleviates urethral dysfunction in diabetic rats through modulating the NO-cGMP pathway.

Exp Ther Med. 2018 Jan;15(1):1053-1061. (IF 1.785)

94. He SW, Wang GH, Yue B, Zhou S, Zhang M

TO17: A teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum, Sciaenops ocellatus.

FISH SHELLFISH IMMUN. 2018 Jan;72:639-645. (IF 3.298)

95. Deng X, Huang W, Peng J, Zhu TT, Sun XL, Zhou XY, Yang H, Xiong JF, He HQ, Xu YH, He YZ.

Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and EndothelialDysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling.

Inflammation. 2018 Feb;41(1):260-275. (IF 3.212)

96. Long Y, Chen SW, Gao CL, He XM, Liang GN, Wu J, Jiang CX, Liu X, Wang F, Chen F.

ATP2B1 GeneSilencing Increases NO Production Under Basal Conditions ThroughtheCa2+/calmodulin/eNOS Signaling Pathway in Endothelial Cells.

Hypertens Res. 2018 Feb 7. (IF 2.941)

97. Deng X, Huang W, Peng J, Zhu TT, Sun XL, Zhou XY, Yang H, Xiong JF, He HQ, Xu YH, He YZ

Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling.

Inflammation. 2018 Feb;41(1):260-275. (IF 3.212)

98. Ma LL, Ma X, Kong FJ, Guo JJ, Shi HT, Zhu JB, Zou YZ, Ge JB.

Mammaliantargetofrapamycin inhibition attenuates myocardial ischaemia-reperfusion injury in hypertrophic heart.

J Cell Mol Med. 2018 Mar;22(3):1708-1719. (IF 4.486)

99. Pan P, Zhang H, Su L, Wang X, Liu D

Melatonin Balance the Autophagy and Apoptosis by Regulating UCP2 in the LPS-Induced Cardiomyopathy.

Molecules. 2018 Mar 16;23(3). pii: E675. (IF 3.267)

100. Tian AL, Lu M, Calderón-Mantilla G, Petsalaki E, Dottorini T, Tian X, Wang Y, Huang SY, Hou JL, Li X, Elsheikha HM, Zhu XQ

A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells.

PARASITE VECTOR. 2018 Mar 6;11(1):152. (IF 2.824)

101. Cui K, Tang Z, Li CC, Wang T, Rao K, Wang SG, Liu JH, Chen Z

Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis.

Asian J Androl. 2018 Mar-Apr;20(2):166-172. (IF 2.448)

102. Ma LL, Ma X, Kong FJ, Guo JJ, Shi HT, Zhu JB, Zou YZ, Ge JB.

Mammalian target of rapamycin inhibition attenuates myocardial ischaemia-reperfusion injury in hypertrophic heart.

J Cell Mol Med. 2018 Mar 22(3):1708-1719. (IF 4.486)

103. Zheng D, Cai A, Xu R, Mai Z, Zhou Y, Zeng F, Li L, Mai W

Effects and potential mechanism of atorvastatin treatment on Lp-PLA2 in rats with dyslipidemia.

Arch Med Sci. 2018 Apr;14(3):629-634. (IF 2.807)

104. Xu C, Shi Q, Zhang L, Zhao H

High molecular weight hyaluronan attenuates fine particulate matter-induced acute lung injury through inhibition of ROS-ASK1-p38/JNK-mediated epithelial apoptosis.

ENVIRON TOXICOL CHEM. 2018 Apr;59:190-198. (IF 3.152)

105. Long Y, Chen SW, Gao CL, He XM, Liang GN, Wu J, Jiang CX, Liu X, Wang F, Chen F

ATP2B1 Gene Silencing Increases NO Production Under Basal Conditions Through the Ca2+/calmodulin/eNOS Signaling Pathway in Endothelial Cells.

Hypertens Res. 2018 Apr;41(4):246-252. (IF 2.941)

106. Peng Y, Hu K

Effect of garlic on rats with chronic intermittent hypoxia combined with diabetes mellitus.

Mol Med Rep. 2018 Apr;17(4):6174-6184. (IF 2.1)

107. Liu S, Zhang C, Chao N, Lu J, Zhang Y

Cloning, Characterization, and Functional Investigation of VaHAESA from Vitis amurensis Inoculated with Plasmopara viticola.

Int J Mol Sci. 2018 Apr 16;19(4). pii: E1204. (IF 4.556)

108. Mao J, Hu X, Pang P, Zhou B, Zhang Y, Li D, Shan H

Establishment of a CRISPR/Cas9-Mediated Cysltr1 Knockout Mouse Model and iTRAQ-Based Proteomic Analysis.

PROTEOM CLIN APPL. 2018 May;12(3):e1700087. (IF 2.489)

109. Zhang Y, Dong F, Liu Z, Guo J, Zhang J, Fang J

Nanosecond pulsed electric fields promoting the proliferation of porcine iliac endothelial cells: An in vitro study.

PLoS One. 2018 May 1;13(5):e0196688. (IF 2.74)

110. Ehsan M, Wang W, Gadahi JA, Hasan MW, Lu M, Wang Y, Liu X, Haseeb M, Yan R, Xu L, Song X, Li X

The Serine/Threonine-Protein Phosphatase 1 From Haemonchus contortus Is Actively Involved in Suppressive Regulatory Roles on Immune Functions of Goat Peripheral Blood Mononuclear Cells.

Front Immunol. 2018 Jul 16;9:1627. (IF 5.085)

111. Luo W, Wang Y, Yang H, Dai C, Hong H, Li J, Liu Z, Guo Z, Chen X, He P, Li Z, Li F, Jiang J, Liu P, Li Z

Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.

AGING-US. 2018 Jul 24;10(7):1722-1744. (IF 4.831)

112. Li H, Chen LP, Wang T, Wang SG, Liu JH

Calpain inhibition improves erectile function in diabetic mice via upregulating endothelial nitric oxide synthase expression and reducing apoptosis.

Asian J Androl. 2018 Jul-Aug;20(4):342-348. (IF 2.448)

113. Ma Y, Tang T, Sheng L, Wang Z, Tao H, Zhang Q, Zhang Y, Qi Z

Aloin suppresses lipopolysaccharide‑induced inflammation by inhibiting JAK1‑STAT1/3 activation and ROS production in RAW264.7 cells.

Int J Mol Med. 2018 Oct;42(4):1925-1934. (IF 3.098)

114. Zhang R, Ji J, Blaženović I, Pi F, Wang T, Zhang Y, Sun X

Investigation into Cellular Glycolysis for the Mechanism Study of Energy Metabolism Disorder Triggered by Lipopolysaccharide.

TOXINS. 2018 Oct 29;10(11). pii: E441. (IF 3.531)

115. Zhang F, Zhang JG, Yang W, Xu P, Xiao YL, Zhang HT

6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation.

Biomed Pharmacother. 2018 Nov;107:1523-1529. (IF 4.545)

116. Luo J, Wei D, Li D, Wang L

Nitric oxide functions in stromal cell-derived factor-1-induced cytoskeleton changes and the migration of Jurkat cells.

Oncol Lett. 2018 Nov;16(5):6685-6690. (IF 2.311)

117. Zhao Z, Zhang H, Wang M, Zhang C, Kuang P, Zhou Z, Zhang G, Wang Z, Zhang B, Shi X

The ethanol extract of honeysuckle stem modulates the innate immunity of Chinese mitten crab Eriocheir sinensis against Aeromonas hydrophila.

FISH SHELLFISH IMMUN. 2018 Nov;82:304-311. (IF 3.298)

118. Liu X, Li X, Wang Q, Sun X, Lu M, Ehsan M, Xu L, Yan R, Song X, Li X

Toxoplasma gondii Histone 4 Affects Some Functions of Murine Ana-1 Macrophages In Vitro.

J Eukaryot Microbiol. 2018 Nov;65(6):860-869. (IF 2.143)

119. Tian AL, Lu M, Zhang FK, Calderón-Mantilla G, Petsalaki E, Tian X, Wang W, Huang SY, Li X, Elsheikha HM, Zhu XQ

The pervasive effects of recombinant Fasciola gigantica Ras-related protein Rab10 on the functions of goat peripheral blood mononuclear cells.

PARASITE VECTOR. 2018 Nov 6;11(1):579. (IF 2.824)

120. Song S, Wu S, Wang Y, Wang Z, Ye C, Song R, Song D, Ruan Y

17β-estradiol inhibits human umbilical vascular endothelial cell senescence by regulating autophagy via p53.

Exp Gerontol. 2018 Dec;114:57-66. (IF 3.376)

121. Yang B, Guo J, Xiao C.

Effect of PM2.5 environmental pollution on rat lung.

ENVIRON SCI POLLUT R. 2018 Dec 25(36):36136-36146. (IF 3.056)

122. Liu W, Xiang Y, Zhang X, Han G, Sun X, Sheng Y, Yan J, Scheller HV, Zhang A

Over-Expression of a Maize N-Acetylglutamate Kinase Gene (ZmNAGK) Improves Drought Tolerance in Tobacco.

Front Plant Sci. 2019 Jan 4;9:1902. (IF 4.402)

123. Deng Y, Cai Y, Liu L, Lin X, Lu P, Guo Y, Han M, Xu G

Blocking Tyr265 nitration of protein phosphatase 2A attenuates nitrosative stress-induced endothelial dysfunction in renal microvessels.

FASEB J. 2019 Mar;33(3):3718-3730. (IF 4.966)

124. Tu X, Qi X, Huang A, Ling F, Wang G

Cytokine gene expression profiles in goldfish (Carassius auratus) during Gyrodactylus kobayashii infection.

FISH SHELLFISH IMMUN. 2019 Mar 86:116-124. (IF 3.298)

125. Zhu B, Li Y, Mei W, He M, Ding Y, Meng B, Zhao H, Xiang G

Alogliptin improves endothelial function by promoting autophagy in perivascular adipose tissue of obese mice through a GLP-1-dependent mechanism.

VASC PHARMACOL. 2019 Apr;115:55-63. (IF 4.152)

126. Li M, Wang M, Wang W, Wang L, Liu Z, Sun J, Wang K, Song L

The immunomodulatory function of invertebrate specific neuropeptide FMRFamide in oyster Crassostrea gigas.

FISH SHELLFISH IMMUN. 2019 May 88:480-488. (IF 3.298)

127. Yan D, Zhang D, Lu L, Qiu H, Wang J

Vascular endothelial growth factor-modified macrophages accelerate reendothelialization and attenuate neointima formation after arterial injury in atherosclerosis-prone mice.

J Cell Biochem. 2019 Jun 120(6):10652-10661. (IF 4.237)

128. Wang Z, Song P, Li Y, Wang S, Fan J, Zhang X, Luan J, Chen W, Wang Y, Liu P, Ju D

Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy.

APPL MICROBIOL BIOT. 2019 Jun 103(12):4825-4838. (IF 3.53)

129. Chang L, Wang Z, Ma F, Tran B, Zhong R, Xiong Y, Dai T, Wu J, Xin X, Guo W, Xie Y, Mao Y, Zhu YZ

ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway.

Oxid Med Cell Longev. 2019 Jun 2 2019:6173685. (IF 5.076)

130. Hao H, Tian W, Pan C, Jiao Y, Deng X, Fan J, Han J, Han S, Wang M, Li P

Marsdenia tenacissima extract dilated small mesenteric arteries via stimulating endothelial nitric oxide synthase and inhibiting calcium influx.

J Ethnopharmacol. 2019 Jun 28 238:111847. (IF 3.69)

131. Yan L, Yang J, Yu M, Lu Y, Huang L, Wang J, Lu X, Jin C, Wu S, Cai Y

Lanthanum chloride induces neuron damage by activating the nuclear factor-kappa B signaling pathway in activated microglia.

Metallomics. 2019 Jul 17 11(7):1277-1287. (IF 3.796)

132. Chen D, Tian AL, Hou JL, Li JX, Tian X, Yuan XD, Li X, Elsheikha HM, Zhu XQ

The Multitasking Fasciola gigantica Cathepsin B Interferes With Various Functions of Goat Peripheral Blood Mononuclear Cells in vitro.

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133. Lu Y, Gao X, Wang R, Sun J, Guo B, Wei R, Jia Y

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